<b>1α,25(OH)</b><b><sub>2</sub></b><b>D</b><b><sub>3</sub></b><b> downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human </b><b>myotubes </b>
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چکیده
منابع مشابه
Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.
Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased transcriptionally in skeletal muscle under atrophy-inducing conditions, making them excellent markers of muscle atrophy. In the past 10 years much has been published about MuRF1 and MAFbx with respect to their mRNA expressi...
متن کاملAMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.
The hypothesis of the present study was that exposure of differentiated muscle cells to agonists of the AMP-activated protein kinase (AMPK) would increase the mRNA content of the muscle-specific ubiquitin ligases muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1). C(2)C(12) cells were incubated with incremental doses of 5-aminoimidazol-4-carboximide ribonucleoside (AICAR) or metformi...
متن کاملGhrelin inhibits skeletal muscle protein breakdown in rats with thermal injury through normalizing elevated expression of E3 ubiquitin ligases MuRF1 and MAFbx.
We previously determined that ghrelin synthesis was downregulated after burn injury and that exogenous ghrelin retained its ability both to stimulate food intake and to restore plasma growth hormone levels in burned rats. These observations and the finding that anabolic hormones can attenuate skeletal muscle catabolism led us to investigate whether ghrelin could attenuate burn-induced skeletal ...
متن کاملSkeletal Muscle Atrophy and the E 3 Ubiquitin Ligases , MuRF 1 and 1 MAFbx / Atrogin -
Skeletal Muscle Atrophy and the E3 Ubiquitin Ligases, MuRF1 and 1 MAFbx/Atrogin-1 2 3 Sue C. Bodine and 1,2,3 and Leslie M. Baehr 2 4 5 Departments of Neurobiology, Physiology, and Behavior 1 ; 6 and Physiology and Membrane Biology 2 7 University of California, Davis, Davis, CA, 95616. 8 Northern California VA Health Systems 3 9 10 Running Head: E3 Ubiquitin Ligases and Sparing of Muscle Mass 1...
متن کاملIGF-1 stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin-ligases, atrogin-1 and MuRF1
1Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. 2Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima, Japan 890-0065 *J.M.S and A.O. contributed equally to this work. Correspondence should be addressed to: Alfred L. Goldberg Phone: (617) 432-1854 Fax: (617) 232-0173 e-mail: a...
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ژورنال
عنوان ژورنال: Biomedical Research
سال: 2015
ISSN: 0388-6107,1880-313X
DOI: 10.2220/biomedres.36.71